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Posts Tagged ‘Indinavir’

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Indinavir by mouth – national library of medicine.

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Indinavir inhibited hiv replication by 95 at concentrations ranging from approximately 25 to 100 nmol l in vitro , and an additive or synergistic antiviral effect was demonstrated in most studies combining indinavir with other antiretroviral agents in cell culture.

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Indirect hyperbilirubinaemia occurs in about 10 of patients treated with indinavir, although there are no known clinical consequences or sequelae.

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Bromocriptine is extensively metabolized in the liver via cyp3a4; indinavir is a strong inhibitor of cyp3a4.

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Indinavir should be used with caution in patients with hepatic disease, including cirrhosis.

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