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    Bupropion and its metabolites are excreted in human breast milkA decision on whether to abstain from breast-feeding or to abstain from therapy with Zyban should be made taking into account the benefit of breast-feeding to the newborn/infant and the benefit of Zyban therapy to the mother.

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    Some epidemiological studies of pregnancy outcomes following maternal exposure to bupropion in the first trimester have reported an association with increased risk of certain congenital cardiovascular malformations specifically ventricular septal defects and left outflow tract heart defectsThese findings are not consistent across studiesAnimal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicitysee section 5.3Zyban should not be used in pregnancyPregnant women should be encouraged to quit smoking without the use of pharmacotherapy.

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